Ebbe Toftgaard Poulsen Selected Research

Hereditary Corneal Dystrophies

1/2021	Mutation-induced dimerization of transforming growth factor-β-induced protein may drive protein aggregation in granular corneal dystrophy.
1/2020	Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies.
1/2019	The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation.
1/2018	Proteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies.
12/2017	Mutation-Induced Deamidation of Corneal Dystrophy-Related Transforming Growth Factor β-Induced Protein.
3/2016	Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
2/2016	LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).
7/2015	Protein Composition of TGFBI-R124C- and TGFBI-R555W-Associated Aggregates Suggests Multiple Mechanisms Leading to Lattice and Granular Corneal Dystrophy.
4/2014	Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene.
1/2013	Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits.

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Ebbe Toftgaard Poulsen Research Topics

Disease

10	Hereditary Corneal Dystrophies 01/2021 - 01/2013
5	Amyloid Plaque 01/2019 - 01/2013
3	Amyloidosis 01/2019 - 01/2013
2	COVID-19 01/2022 - 12/2020
2	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 12/2015
2	Inflammation (Inflammations) 01/2017 - 04/2015
1	Blindness (Hysterical Blindness) 01/2021
1	Virus Diseases (Viral Diseases) 12/2020
1	Infections 12/2020
1	Retinal Detachment (Retinal Detachments) 10/2020
1	Proteostasis Deficiencies 01/2019
1	Vision Disorders (Hemeralopia) 12/2017
1	Juvenile Epithelial of Meesmann Corneal Dystrophy 03/2016
1	Corneal Opacity 03/2016
1	Disease Progression 02/2016
1	Corneal dystrophy Avellino type 02/2016
1	Birth Weight (Birth Weights) 11/2014
1	Autolysis 06/2014
1	Lattice corneal dystrophy type 1 04/2014

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2013
4	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021 - 12/2017
4	Amyloid (Amyloid Fibrils)IBA 01/2020 - 01/2013
3	betaIG-H3 protein (keratoepithelin)IBA 02/2016 - 01/2013
3	Transforming Growth Factor beta (TGF-beta)IBA 07/2015 - 01/2013
2	ProteomeIBA 10/2020 - 04/2014
2	High-Temperature Requirement A Serine Peptidase 1IBA 01/2020 - 01/2013
2	Peptides (Polypeptides)IBA 01/2019 - 04/2014
2	Serine Proteases (Serine Protease)IBA 01/2019 - 01/2013
1	Extracellular Matrix ProteinsIBA 01/2021
1	CytokinesIBA 12/2020
1	Antiviral Agents (Antivirals)IBA 12/2020
1	InterferonsIBA 12/2020
1	Complement System Proteins (Complement)IBA 01/2017
1	Keratins (Keratin)IBA 03/2016
1	Keratin-12 (Keratin 12)IBA 03/2016
1	Histidine (L-Histidine)FDA Link 02/2016
1	Arginine (L-Arginine)FDA Link 02/2016
1	Protein AggregatesIBA 02/2016
1	Amyloidogenic ProteinsIBA 12/2015
1	Eosine Yellowish-(YS) (Eosin)IBA 07/2015
1	Hematoxylin (Haematoxylon)IBA 07/2015
1	Congo RedIBA 07/2015
1	DisulfidesIBA 06/2014
1	Cysteine (L-Cysteine)FDA Link 06/2014
1	ThioredoxinsIBA 06/2014
1	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2014
1	Serum Amyloid P-ComponentIBA 01/2013
1	apolipoprotein A-IV (apolipoprotein AIV)IBA 01/2013
1	ClusterinIBA 01/2013
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2013

Therapy/Procedure

3	Therapeutics 01/2020 - 03/2016
2	Lasers (Laser) 04/2014 - 01/2013
1	Slit Lamp 03/2016
1	Laser In Situ Keratomileusis (LASIK) 02/2016